Is the heat surrounding adipose tissue mitochondria warranted?
نویسندگان
چکیده
منابع مشابه
Brown adipose tissue: The heat is on the heart.
The study of brown adipose tissue (BAT) has gained significant scientific interest since the discovery of functional BAT in adult humans. The thermogenic properties of BAT are well recognized; however, data generated in the last decade in both rodents and humans reveal therapeutic potential for BAT against metabolic disorders and obesity. Here we review the current literature in light of a pote...
متن کاملMitochondria Isolated from Rat Brown Adipose Tissue
Mitochondrial fractions, relatively free from contsmination by other cytopla-~mic structures, have been isolated by differential centrifugation from homogenates of brown adipose tissue from starved rats. It was possible in such fractions to distinguish two types of mitochondria in this tissue. Type I mitochondria, when morphologically intact, are limited by a bilaminar membrane and show regular...
متن کاملAdiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos.
Adiponectin is one of the adipocytokines, which are adipose-specific secretory factors. We examined its expression during embryogenesis. Transcripts of adiponectin were detected at a late stage of embryogenesis on embryonic (E) day E16.5. In situ hybridization showed that adiponectin transcripts were localized in brown adipose tissues (BATs) and surrounding immature tissues in mouse embryos. Im...
متن کاملBrown Adipose Tissue : the Heat is on the Heart 1 2 3
19 20 The study of brown adipose tissue (BAT) has gained significant scientific interest since 21 the discovery of functional BAT in adult humans. The thermogenic properties of BAT are 22 well recognized, however, data generated in the last decade in both rodents and 23 humans reveal therapeutical potential for BAT against metabolic disorders and obesity. 24 Here we review the current literatur...
متن کاملMitochondrial fission: firing up mitochondria in brown adipose tissue.
Brown adipose tissue (BAT) is an important site for energy expenditure, for instance to generate heat in times of cold exposure. BAT expansion and activation can increase energy dissipation of an organism. This involves the coordinated activation of mitochondrial metabolism and heat generation through uncoupling of oxidative phosphorylation. In this issue of The EMBO Journal, the Shirihai group...
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ژورنال
عنوان ژورنال: Current Opinion in Clinical Nutrition and Metabolic Care
سال: 2014
ISSN: 1363-1950
DOI: 10.1097/mco.0000000000000102